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1

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Lovén, Jakob, Hoke, Heather A., Lin, Charles Y., Lau, Ashley, Orlando, David A., Vakoc, Christopher R., Bradner, James E., Lee, Tong Ihn, Young, Richard A.

Journal:

Year:

2013

Language:

english

File:

PDF, 2.06 MB

english, 2013

2

Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation

Gaub, Aline, Sheikh, Bilal N., Basilicata, M. Felicia, Vincent, Marie, Nizon, Mathilde, Colson, Cindy, Bird, Matthew J., Bradner, James E., Thevenon, Julien, Boutros, Michael, Akhtar, Asifa

Journal:

Nature Communications

Year:

2020

File:

PDF, 4.41 MB

2020

3

Ligand-Promoted Meta-C–H Arylation of Anilines, Phenols, and Heterocycles

Wang, Peng, Farmer, Marcus E., Huo, Xing, Jain, Pankaj, Shen, Peng-Xiang, Ishoey, Mette, Bradner, James E., Wisniewski, Steven R., Eastgate, Martin D., Yu, Jin-Quan

Journal:

Journal of the American Chemical Society

Year:

2016

Language:

english

File:

PDF, 1.90 MB

english, 2016

4

Genome-wide localization of small molecules

Anders, Lars, Guenther, Matthew G, Qi, Jun, Fan, Zi Peng, Marineau, Jason J, Rahl, Peter B, Lovén, Jakob, Sigova, Alla A, Smith, William B, Lee, Tong Ihn, Bradner, James E, Young, Richard A

Journal:

Nature Biotechnology

Year:

2013

Language:

english

File:

PDF, 1.03 MB

english, 2013

5

Small-Molecule Inhibition of BRDT for Male Contraception

Matzuk, Martin M., McKeown, Michael R., Filippakopoulos, Panagis, Li, Qinglei, Ma, Lang, Agno, Julio E., Lemieux, Madeleine E., Picaud, Sarah, Yu, Richard N., Qi, Jun, Knapp, Stefan, Bradner, James E.

Journal:

Year:

2012

Language:

english

File:

PDF, 2.61 MB

english, 2012

6

Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance

Marcotte, Richard, Sayad, Azin, Brown, Kevin R., Sanchez-Garcia, Felix, Reimand, Jüri, Haider, Maliha, Virtanen, Carl, Bradner, James E., Bader, Gary D., Mills, Gordon B., Pe’er, Dana, Moffat, Jason,

Journal:

Year:

2016

Language:

english

File:

PDF, 6.14 MB

english, 2016

7

Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions

Ji, Xiong, Dadon, Daniel B., Abraham, Brian J., Lee, Tong Ihn, Jaenisch, Rudolf, Bradner, James E., Young, Richard A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1.90 MB

english, 2015

8

Transcriptional Addiction in Cancer

Bradner, James E., Hnisz, Denes, Young, Richard A.

Journal:

Year:

2017

Language:

english

File:

PDF, 2.80 MB

english, 2017

9

RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity

Pefanis, Evangelos, Wang, Jiguang, Rothschild, Gerson, Lim, Junghyun, Kazadi, David, Sun, Jianbo, Federation, Alexander, Chao, Jaime, Elliott, Oliver, Liu, Zhi-Ping, Economides, Aris N., Bradner, Jame

Journal:

Year:

2015

Language:

english

File:

PDF, 3.10 MB

english, 2015

10

Relative Binding Free Energy Calculations Applied to Protein Homology Models

Cappel, Daniel, Hall, Michelle Lynn, Lenselink, Eelke B., Beuming, Thijs, Qi, Jun, Bradner, James E., Sherman, Woody

Journal:

Journal of Chemical Information and Modeling

Year:

2016

Language:

english

File:

PDF, 1.20 MB

english, 2016

11

Fluorous-Based Small-Molecule Microarrays for the Discovery of Histone Deacetylase Inhibitors

Arturo J. Vegas, James E. Bradner, Weiping Tang, Olivia M. McPherson, Edward F. Greenberg, Angela N. Koehler, Stuart L. Schreiber

Journal:

Angewandte Chemie International Edition

Year:

2007

Language:

english

File:

PDF, 784 KB

english, 2007

12

An epigenomic approach to therapy for tamoxifen-resistant breast cancer

Feng, Qin, Zhang, Zheng, Shea, Martin J, Creighton, Chad J, Coarfa, Cristian, Hilsenbeck, Susan G, Lanz, Rainer, He, Bin, Wang, Lei, Fu, Xiaoyong, Nardone, Agostina, Song, Yongcheng, Bradner, James, M

Journal:

Year:

2014

Language:

english

File:

PDF, 1.04 MB

english, 2014

13

Synthesis of hybrid anticancer agents based on kinase and histone deacetylase inhibitors

Patel, Hiren, Chuckowree, Irina, Coxhead, Peter, Guille, Matthew, Wang, Minghua, Zuckermann, Alexandra, Williams, Robin S. B., Librizzi, Mariangela, Paranal, Ronald M., Bradner, James E., Spencer, Joh

Journal:

Year:

2014

Language:

english

File:

PDF, 325 KB

english, 2014

14

BET and BRAF inhibitors act synergistically against BRAF- mutant melanoma

Paoluzzi, Luca, Hanniford, Douglas, Sokolova, Elena, Osman, Iman, Darvishian, Farbod, Wang, Jinhua, Bradner, James E., Hernando, Eva

Journal:

Cancer Medicine

Year:

2016

Language:

english

File:

PDF, 297 KB

english, 2016

15

Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands

Remillard, David, Buckley, Dennis L., Paulk, Joshiawa, Brien, Gerard L., Sonnett, Matthew, Seo, Hyuk-Soo, Dastierdi, Shiva, Wühr, Martin, Dhe-Paganon, Sirano, Armstrong, Scott A., Bradner, James E.

Journal:

Angewandte Chemie

Year:

2017

Language:

english

File:

PDF, 3.50 MB

english, 2017

16

On the inhibition of histone deacetylase 8

Guillermina Estiu, Nathan West, Ralph Mazitschek, Edward Greenberg, James E. Bradner, Olaf Wiest

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.27 MB

english, 2010

17

Complement 3 and Factor H in Human Cerebrospinal Fluid in Parkinson's Disease, Alzheimer's Disease, and Multiple-System Atrophy

Yu Wang, Aneeka M. Hancock, Joshua Bradner, Kathryn A. Chung, Joseph F. Quinn, Elaine R. Peskind, Douglas Galasko, Joseph Jankovic, Cyrus P. Zabetian, Hojoong M. Kim, James B. Leverenz, Thomas J. Mont

Journal:

The American Journal of Pathology

Year:

2011

Language:

english

File:

PDF, 1.01 MB

english, 2011

18

Modulation of Signaling Cascades by Inhibitors of Histone Deacetylase and Akt

Hideshima, Teru, Ikeda, Hiroshi, Mitsiades, Constantine C., Chauhan, Darminder, Bradner, James E., Munshi, Nikhil C., Richardson, Paul G., Anderson, Kenneth C.

Journal:

Clinical Lymphoma & Myeloma

Year:

2009

Language:

english

File:

PDF, 95 KB

english, 2009

19

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

Bradner, James E., Mak, Raymond, Tanguturi, Shyam K., Mazitschek, Ralph, Haggarty, Stephen J., Ross, Kenneth, Chang, Cindy Y., Bosco, Jocelyn, West, Nathan, Morse, Elizabeth, Lin, Katherine, Shen, Joh

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 686 KB

english, 2010

20

Direct inhibition of the NOTCH transcription factor complex

Moellering, Raymond E., Cornejo, Melanie, Davis, Tina N., Bianco, Cristina Del, Aster, Jon C., Blacklow, Stephen C., Kung, Andrew L., Gilliland, D. Gary, Verdine, Gregory L., Bradner, James E.

Journal:

Year:

2010

File:

PDF, 31 KB

2010

21

Comparative seismic noise on the ocean bottom and on land

Bradner, Hugh, Dodds, James G.

Journal:

Journal of Geophysical Research

Year:

1964

Language:

english

File:

PDF, 744 KB

english, 1964

22

Cancer: An essential passenger with p53

Bradner, James E.

Journal:

Year:

2015

Language:

english

File:

PDF, 159 KB

english, 2015

23

Poetry Corner

James H. Bradner, Jr., Reuben Lozner and Louis M. Sussholz

Journal:

American Bar Association Journal

Year:

1975

Language:

english

File:

PDF, 205 KB

english, 1975

24

Synthesis and Biochemical Evaluation of Biotinylated Conjugates of Largazole Analogues: Selective Class I Histone Deacetylase Inhibitors

Zhao, Le, Dunne, Christine E., Clausen, Dane J., Roberts, Justin M., Paulk, Joshiawa, Liu, Haining, Wiest, Olaf G., Bradner, James E., Williams, Robert M.

Journal:

Israel Journal of Chemistry

Year:

2017

Language:

english

File:

PDF, 4.19 MB

english, 2017

25

A cyclodextrin-capped histone deacetylase inhibitor

Amin, Jahangir, Puglisi, Antonino, Clarke, James, Milton, John, Wang, Minghua, Paranal, Ronald M., Bradner, James E., Spencer, John

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 476 KB

english, 2013

26

Inhibitors of emerging epigenetic targets for cancer therapy: a patent review (2010–2014)

Tanaka, Minoru, Roberts, Justin M, Qi, Jun, Bradner, James E

Journal:

Pharmaceutical Patent Analyst

Year:

2015

Language:

english

File:

PDF, 1.94 MB

english, 2015

27

Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold

Remillard, David, Buckley, Dennis L., Seo, Hyuk-Soo, Ferguson, Fleur M., Dhe-Paganon, Sirano, Bradner, James E., Gray, Nathanael S.

Journal:

ACS Medicinal Chemistry Letters

Year:

2019

Language:

english

File:

PDF, 12.23 MB

english, 2019

28

MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia

Chen, Chong, Liu, Yu, Rappaport, Amy R., Kitzing, Thomas, Schultz, Nikolaus, Zhao, Zhen, Shroff, Aditya S., Dickins, Ross A., Vakoc, Christopher R., Bradner, James E., Stock, Wendy, LeBeau, Michelle M

Journal:

Year:

2014

Language:

english

File:

PDF, 3.79 MB

english, 2014

29

Non-overlapping Promoter and Super-enhancer Driven Processes Support Myeloma Cell Growth and Survival via Distinct Regulatory Axes

Fulciniti, Mariateresa, Lin, Charles, Samur, Mehmet, Young, Rick, Anderson, Kenneth C., Avet-Loiseau, Herve, Bradner, James, Munshi, Nikhil

Journal:

Clinical Lymphoma Myeloma and Leukemia

Year:

2017

Language:

english

File:

PDF, 68 KB

english, 2017

30

Antitumor and DNA-binding properties of a group of oligomeric complexes of platinum(II) and platinum(IV)

Peritz, Adam, Al-Baker, Salaam, Vollano, Jean F., Dabrowiak, James C., Schurig, John E., Bradner, William T.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 2.47 MB

english, 1990

31

Use of theory in computer-based interventions to reduce alcohol use among adolescents and young adults: a systematic review

Tebb, Kathleen P., Erenrich, Rebecca K., Jasik, Carolyn Bradner, Berna, Mark S., Lester, James C., Ozer, Elizabeth M.

Journal:

BMC Public Health

Year:

2016

Language:

english

File:

PDF, 787 KB

english, 2016

32

Targeting the epigenetic readers in Ewing Sarcoma inhibits the oncogenic transcription factor EWS/Fli1

Jacques, Camille, Lamoureux, François, Baud’huin, Marc, Calleja, Lidia Rodriguez, Quillard, Thibaut, Amiaud, Jérôme, Tirode, Franck, Rédini, Françoise, Bradner, James E., Heymann, Dominique, Ory, Benj

Journal:

Year:

2016

Language:

english

File:

PDF, 8.31 MB

english, 2016

33

Effect of Thrombocytopenia on Outcomes Following Treatment With Either Enoxaparin or Unfractionated Heparin in Patients Presenting With Acute Coronary Syndromes

Robert W. Yeh, Stephen D. Wiviott, Robert P. Giugliano, David A. Morrow, Amy Shui, Jie Qin, Benjamin Scirica, James E. Bradner, Ik-Kyung Jang, C. Michael Gibson, Elliott M. Antman

Journal:

The American Journal of Cardiology

Year:

2007

Language:

english

File:

PDF, 136 KB

english, 2007

34

Comparative pharmacokinetic properties and antitumor activity of the marine HDACi Largazole and Largazole peptide isostere

Pilon, John L., Clausen, Dane J., Hansen, Ryan J., Lunghofer, Paul J., Charles, Brad, Rose, Barbara J., Thamm, Douglas H., Gustafson, Daniel L., Bradner, James E., Williams, Robert M.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.41 MB

english, 2015

35

Antitumor activity of chrysomycins M and V.

MATSON, JAMES A., ROSE, WILLIAM C., BUSH, JAMES A., MYLLYMAKI, ROBERT, BRADNER, WILLIAM T., DOYLE, TERRENCE W.

Journal:

The Journal of Antibiotics

Year:

1989

Language:

english

File:

PDF, 177 KB

english, 1989

36

A chemical probe toolbox for dissecting the cancer epigenome

shortt, Jake, Ott, Christopher J., Johnstone, Ricky W., Bradner, James E.

Journal:

Nature Reviews Cancer

Year:

2017

File:

PDF, 48 KB

2017

37

Tallysomycin S10b: Experimental antitumor activity and toxicity

John E. Schurig, William C. Rose, Robert S. Hirth, Abraham Schlein, James B. Huftalen, Alexander P. Florczyk, William T. Bradner

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1984

Language:

english

File:

PDF, 730 KB

english, 1984

38

Chromatin modifications as therapeutic targets in MLL-rearranged leukemia

Aniruddha J. Deshpande, James Bradner, Scott A. Armstrong

Journal:

Trends in Immunology

Year:

2012

Language:

english

File:

PDF, 752 KB

english, 2012

39

Pre-Clinical Analysis of Changes in Intra-cellular Biochemistry of Glioblastoma Multiforme (GBM) Cells Due to c-Myc Silencing

Rajagopalan, Vishal, Vaidyanathan, Muthukumar, Janardhanam, Vanisree Arambakkam, Bradner, James E.

Journal:

Cellular and Molecular Neurobiology

Year:

2014

Language:

english

File:

PDF, 1.94 MB

english, 2014

40

Epigenetic Reprogramming of Lineage-Committed Human Mammary Epithelial Cells Requires DNMT3A and Loss of DOT1L

Breindel, Jerrica L., Skibinski, Adam, Sedic, Maja, Wronski-Campos, Ania, Zhou, Wenhui, Keller, Patricia J., Mills, Joslyn, Bradner, James, Onder, Tamer, Kuperwasser, Charlotte

Journal:

Stem Cell Reports

Year:

2017

Language:

english

File:

PDF, 2.20 MB

english, 2017

41

JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias

Kim, Sang-Kyu, Knight, Deborah A., Jones, Lisa R., Vervoort, Stephin, Ng, Ashley P., Seymour, John F., Bradner, James E., Waibel, Michaela, Kats, Lev, Johnstone, Ricky W.

Journal:

Genes & Development

Year:

2018

Language:

english

File:

PDF, 4.63 MB

english, 2018

42

ChemInform Abstract: Discovery of Histone Deacetylase 8 Selective Inhibitors.

Weiping Tang, Tuoping Luo, Edward F. Greenberg, James E. Bradner, Stuart L. Schreiber

Journal:

Year:

2012

File:

PDF, 30 KB

2012

43

A method for the covalent capture and screening of diverse small molecules in a microarray format

Bradner, James E, McPherson, Olivia M, Koehler, Angela N

Journal:

Bioentrepreneur

Year:

2006

Language:

english

File:

PDF, 315 KB

english, 2006

44

Tag and Capture Flow Hydrogen Exchange Mass Spectrometry with a Fluorous-Immobilized Probe

Marcsisin, Sean R., Liptak, Cary, Marineau, Jason, Bradner, James E., Engen, John R.

Journal:

Analytical Chemistry

Year:

2015

Language:

english

File:

PDF, 1.60 MB

english, 2015

45

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

James E. Bradner, Raymond Mak, Shyam K. Tanguturi, Ralph Mazitschek, Stephen J. Haggarty, Kenneth Ross, Cindy Y. Chang, Jocelyn Bosco, Nathan West, Elizabeth Morse, Katherine Lin, John Paul Shen, Nich

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.73 MB

english, 2010

46

Design and characterization of bivalent BET inhibitors

Tanaka, Minoru, Roberts, Justin M, Seo, Hyuk-Soo, Souza, Amanda, Paulk, Joshiawa, Scott, Thomas G, DeAngelo, Stephen L, Dhe-Paganon, Sirano, Bradner, James E

Journal:

Nature Chemical Biology

Year:

2016

Language:

english

File:

PDF, 1.15 MB

english, 2016

47

ELUCIDATING THE RELATIONSHIP BETWEEN HYPERPHOSPHORYLATED TAU AND LOCUS COERULEUS DEGENERATION IN ALZHEIMER’S DISEASE

Chalermpalanupap, Termpanit, Bradner, Josh, Chen, Tracy, Jerome, Canaan, Schroeder, Jason, Lah, James J., Tansey, Malu G., Levey, Allan I., Weinshenker, David

Journal:

Alzheimer's & Dementia

Year:

2016

Language:

english

File:

PDF, 48 KB

english, 2016

48

PDTM-34. COMBINED BET BROMODOMAIN AND CDK2 INHIBITION IN MYC-DRIVEN MEDULLOBLASTOMA

Bolin, Sara, Borgenvik, Anna, Persson, Camilla, Sundström, Anders, Qi, Jun, Bradner, James, Weiss, William, Cho, Yoon-Jae, Weishaupt, Holger, Swartling, Fredrik

Journal:

Year:

2017

File:

PDF, 87 KB

2017

49

HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer

Hideshima, Teru, Mazitschek, Ralph, Qi, Jun, Mimura, Naoya, Tseng, Jen-Chieh, Kung, Andrew L., Bradner, James E., Anderson, Kenneth C.

Journal:

Year:

2017

Language:

english

File:

PDF, 3.13 MB

english, 2017

50

Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease

McCarroll, Steven A, Bradner, James E, Turpeinen, Hannu, Volin, Liisa, Martin, Paul J, Chilewski, Shannon D, Antin, Joseph H, Lee, Stephanie J, Ruutu, Tapani, Storer, Barry

Journal:

Nature Genetics

Year:

2009

Language:

english

File:

PDF, 279 KB

english, 2009

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